dNAT rule looks fine, as destination address you could specify VTUN interface address.
However, on 2nd reading, I believe synology should still be reachable on port 5000 WAN , not from VTUN.
This means you don't need dNAT , but PBR rule needs an exclusion:
modify OPENVPN_ROUTE { rule 5 { action accept description "ReturnTrafficPortMappingSynology" source { address 192.168.2.21/32 port 5000 }
protocol tcp_udp } }